Jannik Sinner and Kateřina Siniaková will take on Belinda Bencic, and Alexandra Zverev in the US Open mixed doubles tournament.
Emma Raducanu and Carlos Alcaraz will face the No. 1-seeded team in the first round.
The remainder of the 16-team field was completed on Monday, and the draw was conducted ahead of the two-day event that begins on Tuesday and pays $1 million to the winning team.
Alcaraz and Raducanu, both past US Open singles champions, will face the team of Jessica Pegula and Jack Draper, who drew the No. 1 seed based on the lowest combined singles rankings.
The top-ranked Sinner will now play with 10-time women’s doubles major champion Katerina Siniakova. He had been scheduled to team with Emma Navarro, before she withdrew to play in the women’s tournament in Monterrey, Mexico, next week.
The other teams added to the event are two-time US Open women’s champion Naomi Osaka, and Gael Monfils, Karolina Muchova, and Andrey Rublev, and Caty McNally and Lorenzo Musetti.
Musetti had been scheduled to play with fellow Italian Jasmine Paolini, but she was playing Iga Swiatek in the Cincinnati final Monday and withdrew. Swiatek remains in the field with partner Casper Ruud.
Sinner and the second-ranked Alcaraz face off in the men’s final.
Sinner and Siniakova, who were given one of the eight wild cards, will open their campaign against the team of Alexander Zverev and Belinda Bencic.
Novak Djokovic will play his first match since the Wimbledon semi-finals as he teams up with Olga Danilovic, as they take on Mirra Andreeva and Daniil Medvedev.
The remaining first-round matchups: Olga Danilovic and Novak Djokovic vs. Mirra Andreeva and Daniil Medvedev; No. 3 Swiatek and Ruud vs. Madison Keys and Frances Tiafoe; Osaka and Monfils vs. McNally and Musetti; Taylor Townsend and Ben Shelton vs. No. 4 Amanda Anisimova and Holger Rune; Venus Williams and Reilly Opelka vs. Muchova and Rublev; and No. 2 Elena Rybakina and Taylor Fritz vs. Sara Errani and Andrea Vavassori.
Errani and Vavassori are the defending US Open champions and the only traditional doubles team in the field.
The first and second rounds will be played on Tuesday while the semifinals, and final will take place on Wednesday night.
US Open Mixed Doubles draw
Draper & Pegula vs Raducanu & Alcaraz
Djokovic & Danilovic vs Andreeva & Medvedev
Swiatek & Ruud vs Keys & Tiafoe
Osaka & Monfils vs McNally & Musetti
Siniakova & Sinner vs Bencic & Zverev
Townsend & Shelton vs Anisimova & Rune
Williams & Opelka vs Muchova & Rublev
Errani & Vavassori vs Rybakina & Fritz
